Who should not take echinacea?

People with tuberculosis, leukemia, diabetes, connective tissue disorders, multiple sclerosis, HIV or AIDS, any autoimmune diseases, or, possibly, liver disorders should not take echinacea. There is some concern that echinacea may reduce the effectiveness of medications that suppress the immune system.

mountsinai.org - Echinacea Information | Mount Sinai - New York

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Echinacea is one of the most popular herbs in America today. Echinacea is a Native American medicinal plant named for the prickly scales in its large conical seed head, which resembles the spines of an angry hedgehog (echinos is Greek for hedgehog). Archaeologists have found evidence that Native Americans may have used echinacea for more than 400 years to treat infections and wounds, and as a general "cure-all." Throughout history people have used echinacea to treat scarlet fever, syphilis, malaria, blood poisoning, and diphtheria. Although this herb was popular during the 18th and 19th centuries, its use began to decline in the United States after the introduction of antibiotics. Echinacea preparations became increasingly popular in Germany throughout the 20th century. In fact, most of the scientific research on echinacea has been conducted in Germany. Today, people use echinacea to shorten the duration of the common cold and flu, and reduce symptoms, such as sore throat (pharyngitis), cough, and fever. Many herbalists also recommend echinacea to help boost the immune system and help the body fight infections.

General Uses

Several laboratory and animal studies suggest that echinacea contains active substances that boost immune function, relieve pain, reduce inflammation, and have hormonal, antiviral, and antioxidant effects. For this reason, professional herbalists may recommend echinacea to treat urinary tract infections, vaginal yeast (candida) infections, ear infections (also known as otitis media), athlete's foot, sinusitis, hay fever (also called allergic rhinitis), as well as slow-healing wounds. Preliminary studies in the lab suggest echinacea may help inhibit colon tumors when combined with cichoric acid. One study even suggests that echinacea extract exerted an antiviral action on the development of recurrent cold sores triggered by the herpes simplex virus (HSVI) when taken prior to infection.

Common Cold

Whether or not echinacea helps prevent or treat the common cold remains controversial. Some studies have shown that the herb can make you feel better faster. Others suggest that echinacea has no impact on a cold at all. Several clinical trials have shown that people who take echinacea as soon as they feel sick reduce the severity of their cold and have fewer symptoms than those who do not take the herb. One study of 95 people with early symptoms of cold and flu (such as runny nose, scratchy throat, and fever) found that those who drank several cups of echinacea tea every day for 5 days felt better sooner than those who drank tea without echinacea. A review of 14 clinical trials found that echinacea reduced the odds of developing a cold by 58% and the duration of a cold by 1 to 4 days. However, some experts dispute these findings claiming there were several weaknesses in the analyses. Echinacea preparations tested in clinical trials differ greatly. It is important to choose a high-quality echinacea supplement, and to use echinacea as early as possible in the course of a cold, with multiple doses per day for the first few days. Talk to your health care provider for recommendations.

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What can you not mix quercetin with?

Be careful if you are taking drugs such as antibiotics, cyclosporine, warfarin, or drugs that are changed by the liver. Quercetin may change how these drugs work and raise the risk of side effects.

webmd.com - Quercetin: Uses and Risks - WebMD

Quercetin is a plant pigment (flavonoid) that people sometimes take as a medicine. It is found in many plants and foods. Most studies look at the impact of flavonoids like quercetin within the diet rather than as a supplement. Why do people take quercetin? People take quercetin to try to manage a variety of issues, including: Heart and vessel problems

Lowering blood pressure

Prostate infections

Preventing upper respiratory infections

Allergies

Disease prevention Early quercetin research on heart and vessel disease is mixed. Some study results are positive but some are open to debate. For example, researchers link eating lots of foods high in quercetin to a lower risk of heart-related death in older men. But other studies are less convincing. Some research suggests that oral doses of quercetin may decrease pain from prostate infections. Some athletes try to increase endurance and improve athletic performance by using quercetin. Although animal studies are promising, the effects in humans, if any, are likely small. One of the biggest benefits to athletes taking quercetin is in protection from URI after intense workouts.

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