What is the newest treatment for wrinkles?

everydayhealth.com - Daxxify: 8 Things to Know About the New Botox Alternative

What does a damaged colon feel like?

If you have a gastrointestinal or bowel perforation, you may experience: Abdominal pain or cramping, which is usually severe. Bloating or a swollen...

Last updated Jun 9, 2019

What does cucumber and pineapple do to your body?

Pineapple and Cucumber Juice is a vitamin C and iron rich express to prevent the skin from drying out and to reduce facial lines. Vitamin C, in...

Last updated Mar 20, 2021

Purple weed obliterates 72lbs of flab

The main ingredient for a potent powdered supplement, based on the diets of among the healthiest, longest-living hamlet in the world.

Learn More »

Promotion

The U.S. Food and Drug Administration (FDA) has approved Daxxify, a new injected medicine for smoothing facial wrinkles in adults, which dermatologists see as the first major competitor to Botox to emerge in decades. Daxxify is in a family of medicines known as neuromodulators, which includes the drugs Botox, Dysport, Xeomin, and Jeuveau. The effects of these established neuromodulators typically last about three months, according to the American Society for Dermatologic Surgery (ASDS). What’s different about Daxxify is that it may keep wrinkles at bay for even longer. In clinical trials submitted to the FDA for approval, 80 percent of people using Daxxify had no or minimally visible facial wrinkles after four months, and roughly half of participants still had little evidence of wrinkles at six months. “Daxxify will definitely change the neuromodulator market because of its increased longevity,” says Joshua Zeichner, MD, an associate professor and the director of cosmetic and clinical research in the department of dermatology at Mount Sinai Hospital in New York City. The path to approval for Daxxify wasn’t completely wrinkle-free, however. An FDA inspection of the Daxxify manufacturing plant in June 2021 identified problems with quality control and what’s known as the working cell bank, or cells with the active ingredient in the drug. Revance, the company that makes Daxxify, stressed in a January 2022 statement that the FDA had concerns with the manufacturing facility but not with the safety or effectiveness of the new drug.

Here’s what else dermatologists want you to know about Daxxify.

1. Daxxify Works Similarly to Botox

Neuromodulators, a family of medicines that includes Daxxify and Botox, essentially freeze wrinkles by injecting a minute amount of botulinum toxin into underlying muscle, causing the tissue to relax and create a smoother appearance for overlying skin, according to the ASDS. The effect wears off over time, and many people get multiple injections each year in order to maintain the look of wrinkle-free skin.

2. But Daxxify Is Different From Botox in Other Ways

One thing that sets Daxxify apart from Botox and other neuromodulators is its duration of effectiveness, dermatologists say. “While most of the other products are reported to last somewhere in the range of three to five months, most patients only get about a three-month effect,” Dr. Zeichner says. “The results with Daxxify are reported to last around six months, which ultimately means fewer trips to the office and happier patients.” In addition, Botox and other neuromodulators are made from what’s known as human serum albumin, says Nazanin Saedi, MD, a board-certified dermatologist at Dermatology Associates of Plymouth Meeting and a clinical associate professor at Thomas Jefferson University in Philadelphia. Daxxify doesn’t contain any human or animal products, and is instead made from peptides or amino acids. Peptides may help make Daxxify last longer as a wrinkle-smoother than other neuromodulators, dermatologists say. And, unlike Botox and some other neuromodulators that require refrigeration, Daxxify can be stored at room temperature, Dr. Saedi says. (Xeomin also does not require refrigeration.)

3. In Studies, Daxxify Worked to Treat Wrinkles in Most People

The FDA approved Daxxify on the basis of clinical trial data collected on more than 2,700 patients, who received a total of 4,200 treatments. One month after injections, 98 percent of patients had little or no appearance of wrinkles. Half of patients were completely or nearly wrinkle-free at the injection area after six months, and some people still had results after nine months.

How much weight can you lose on 7 day juice diet?

Yes, research shows that people can lose 1-2lbs of weight per day on a juice cleanse. Ultimately, this figure is influenced by your starting...

Last updated Feb 8, 2019

What should I take in the morning to lose weight?

Healthy morning drinks for weight loss Lemon water with chia seeds. Both lemon water and chia seeds are beneficial for weight loss. ... Green tea....

Last updated Feb 12, 2019

Purple weed obliterates 72lbs of flab

The main ingredient for a potent powdered supplement, based on the diets of among the healthiest, longest-living hamlet in the world.

Learn More »

Promotion

Can I rub honey on my face overnight?

Applying honey to the skin overnight is an effective way to balance oily skin and reduce excess oil production. It gives skin that healthy, dewy...

Last updated May 6, 2021

How many times a day should I drink lemon water to lose weight?

Stephens recommends using the juice from two to three lemons (about four to six tablespoons) throughout the day, and drinking one or two glasses of...

Last updated Nov 29, 2022

Fizzy juice “eats through” 59lbs of stubborn fat

This effective juice jolts the metabolism, boosts energy and burns fat all day.

Learn More »

Promotion

How much oatmeal is too much in a day?

The staple food contains everything you need to achieve this goal: Carbohydrates, protein, potassium, calcium, sodium, magnesium, many vitamins and...

Last updated Jun 19, 2020

Purple weed obliterates 72lbs of flab

The main ingredient for a potent powdered supplement, based on the diets of among the healthiest, longest-living hamlet in the world.

Learn More »

Promotion

Which foods cause bloating?

13 Foods That Cause Bloating (and What to Eat Instead) Beans. Lentils. Carbonated drinks. Wheat. Broccoli. Onions. Barley. Rye. More items...

Last updated May 23, 2019