What are 3 diseases that affect the adrenal glands?

Some of the most common include: Addison's disease, also called adrenal insufficiency. In this disorder, you don't produce enough cortisol and/or aldosterone. Cushing's syndrome. ... Congenital adrenal hyperplasia. ... Adrenal gland suppression. ... Hyperaldosteronism. ... Virilization.

my.clevelandclinic.org - Adrenal Disorders: What They Are, Types & Symptoms - Cleveland Clinic

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Overview

What are adrenal disorders?

There are many conditions that can lead to problems with the adrenal gland function. The adrenal glands are small and shaped liked triangles and are located just above each kidney. They are sometimes called suprarenal glands. Their job is to make hormones that you need to keep your metabolism, blood pressure, immune system and stress response in balance. Adrenal disorders are the result of your glands making too much or not enough of certain hormones. Hormones produced by the adrenals include hydrocortisone (also called cortisol), adrenaline and aldosterone. You can think of dominoes and how one movement by one domino sets off a chain reaction, making the next domino in line fall down. If something happens and the next domino doesn’t get the message, the effect is ruined.

What are common types of adrenal disorders?

There are different conditions related to your adrenal glands. Some of the most common include: Addison’s disease, also called adrenal insufficiency. In this disorder, you don’t produce enough cortisol and/or aldosterone. Cushing’s syndrome. In this disorder, your levels of cortisol are too high. This term can be applied when large doses of steroids are given to treat certain medical conditions. Congenital adrenal hyperplasia. This term refers to genetic condition in which your adrenal glands are not able to make cortisol well. As a result ACTH is elevated. Depending on the defect higher levels of male hormone might be made. Adrenal gland suppression. This is a type of adrenal insufficiency that is related to outside sources of cortisol or related synthetic hormones such as prednisone or dexamethasone. Hyperaldosteronism. If you have this condition, your body produces too much aldosterone which can lead to blood pressure elevation and potassium loss. Virilization. This condition happens when your body produces too much of the male sex hormones and is only apparent in females or boys before puberty. There are also conditions of the adrenal glands related to growths (tumors). These include:

Adrenal gland tumors. Tumors can disrupt hormone output, but are usually noncancerous.

Adrenocortical carcinoma. This rare condition refers to cancer forming in the adrenal gland’s outer layer. Pheochromocytoma. If you have this condition, your glands make too much epinephrine and norepinephrine which can raise blood pressure or make your heart race. Pituitary tumors. Abnormal growth on the pituitary gland can cause adrenal gland conditions by disrupting the amount of hormones made by the adrenal glands. ACTH producing tumors cause Cushing’s disease. If tumors are large enough, they may press on the normal pituitary cells and cause deficiency of ACTH and secondary adrenal insufficiency.

How common are adrenal disorders?

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Adrenal disorders can happen to anyone. Within the individual conditions, some of them may happen more often to females than males, such as Cushing’s syndrome.

What is adrenal insufficiency?

Adrenal insufficiency happens when the adrenal glands don’t produce enough cortisol and sometimes aldosterone. The production decreases when the adrenal cortex (the glands’ outer layer) is destroyed. This occurs most often when you have an autoimmune disease that causes your body to attack the glands. It can also be caused by tumors, tuberculosis and other types of infections. This condition is known as primary adrenal insufficiency. Secondary adrenal insufficiency, which is more common than the primary form, happens because you don’t have enough of adrenocorticotropin (ACTH), the hormone secreted by the pituitary gland. If your pituitary doesn’t make enough ACTH, your adrenal glands don’t make enough cortisol. Secondary adrenal insufficiency most often happens when you have been taking glucocorticoids (like prednisone) for an extended amount of time and then stop too quickly rather than tapering down gradually. It can also develop due to tumors in the pituitary glands pressing on the normal pituitary cells or from surgery or radiation to the pituitary gland.

What does adrenal crisis mean?

Adrenal crisis is a medical emergency. It’s the most serious complication of adrenal insufficiency and happens due to a severe lack of cortisol. An adrenal crisis can be life-threatening. Symptoms of adrenal crisis include:

Severe pain in your lower body that comes on quickly.

Bouts of vomiting and diarrhea.

Weakness.

Confusion and loss of consciousness.

Low blood glucose,

Low blood pressure.

If you have adrenal insufficiency, you should always have an injectable form of glucocorticoid medicine with you and you should wear some type of medical alert jewelry with that information. Make sure your family and friends know how to give the injection in the case of an emergency. Other hormone imbalances and symptoms can occur with adrenal disorders. These include having too much potassium (hyperkalemia) or not enough sodium (hyponatremia) in your blood.

my.clevelandclinic.org - Adrenal Disorders: What They Are, Types & Symptoms - Cleveland Clinic

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