Smoothy Slim
Photo: Karolina Grabowska
Lychee and ackee fruit can cause acute illness and death, while cassava and grasspea cause a slower crippling paralysis as well as other neurologic deficits. These foods are grown and eaten in large quantities mostly in poor countries.
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Learn More »There are a lot of plants eaten for food that may also contain toxins that harm the brain and the nervous system, when present in amounts that cross the limit of individual tolerance. This happens when such toxin-containing foods are the chief or only source of nutrition. Neurologic disease caused by food toxins is probably more common than that caused by food contamination with manmade chemicals like the infamous Minamata poisonings of a whole fishing community, or the Chinese adulteration of infant formula with melamine. Researchers say, “the adverse neurological effects of food dependency on plant components with toxic potential constitutes a significant global health issue.” Some of these foods include unripe lychee and ackee fruits which can cause acute encephalopathy if overeaten; cassava (either the tuberous root or the leaves) or grasspea, which are linked to subacute spastic weakness of the lower limbs, and cassava root flour which can result in the inability to walk straight (ataxic neuropathy). This situation happens in chronic food scarcity, malnutrition, vitamin deficiency disorders, inadequate removal of the toxins by proper cooking practices, or in some cases, genetic predisposition to the toxin. Lychee and ackee fruit can cause acute illness and death, while cassava and grasspea cause a slower crippling paralysis as well as other neurologic deficits. These foods are grown and eaten in large quantities mostly in poor countries. Reliance on such foods often increases with crop failure or large-scale movement of people from their homes as in wartime. These plants grow well in drought, waterlogged soil, and survive strong winds and wildfires. Poor or dry soil can also cause higher concentrations of toxins within these foods. In such a setting they may become the primary source of nutrition, and may cause disease among a significant number of people. The amount eaten, the nutritional status, and the availability of other foods all play a role in deciding whether these foods help or harm the person.
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Learn More »Lychee fruit also causes fruit poisoning the same way, when eaten unripe. In areas of lychee production, outbreaks of acute encephalitis syndrome occur in the harvest seasons, when poorly fed children pounce on the fruit including the unripe ones, to wake in the morning with hypoglycemic seizures, ending in coma and death. Lychee poisoning has been reported in India, Asia, Bangladesh, Vietnam, and China. The treatment of both lychee and ackee poisoning is to give 10% glucose solution intravenously, while also correcting the salt-water and acid-base imbalance. Untreated, the illness causes repeated vomiting and seizures followed by coma and death.
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Learn More »Cassava neuropathy can also cause tropical ataxic neuropathy. This is seen in a Nigerian Yoruba population and includes sensory symptoms, optical atrophy, and ataxia due to degeneration of the posterior spinal cord. The symptoms may improve after stopping the intake of cassava with thiamine supplementation. Damage to the motor neurons, parkinsonism and cerebellar ataxia, with dementia, form various parts of the spectrum of neurological cassava poisoning. The suspected culprit is cyanate formation (rather than thiocyanate formation, which requires sulfur from dietary proteins) in malnourished individuals, which causes axonal damage. Cognitive deficits may also occur. Prevention of cassava-associated toxicity is by using strains with low levels of toxins, better detoxication processes, free availability of a wider range of nutritional foodstuffs, and broader measures to help farmers deal with climate variation and reduced water availability.
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