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Instead of a blood test, a histamine test performed on urine collected over a 24-hour period may be ordered instead to evaluate histamine production over a longer time frame. In some cases, the metabolite N-methylhistamine may be measured in urine instead of histamine.
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Learn More »Histamine is a substance that is released from specialized cells called mast cells when they are activated, often as part of an allergic immune response. This test measures the amount of histamine in the blood or urine. Mast cells are large tissue cells found throughout the body. They are present mainly in the skin, the lining of the intestine and air passages, and the bone marrow. Mast cells are part of the body’s normal response to injury as well as allergic (hypersensitivity) responses. They contain granules that store a number of chemicals, including histamine and tryptase, which are released when mast cells become activated. Histamine is responsible for many of the symptoms in persons with allergies. Concentrations of histamine in the blood and urine are normally very low. Significant increases can be seen in people with a severe allergic reaction and in those with a disorder in which the number of mast cells increase (proliferate) and/or activate without apparent allergies. The activation of many mast cells is associated with a severe form of acute allergic reaction termed anaphylaxis, which can cause hives (blisters on the skin), reddening of the skin (flushing), low blood pressure, severe narrowing of the air passages, and even death. With anaphylaxis, histamine concentrations in the blood increase rapidly, rising within 10 minutes of the start of symptoms and returning to normal within about 30 to 60 minutes. This increased production is also reflected a short time later in the urine as histamine and its primary metabolite, N-methylhistamine, are excreted. Histamine and tryptase levels may be persistently increased in people with mastocytosis. This rare condition is associated with abnormal proliferation of mast cells and their infiltration and accumulation in the skin (cutaneous mastocytosis) and/or in organs throughout the body (systemic mastocytosis).
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Learn More »A vitamin B12 injection also releases (a lot of) histamine from the mast cells. When there is a lot of free histamine in our body, there is an elevated histamine level.
Histamine is a substance that plays an important role in a large number of processes in our bodies. An example of this is with our sleep-wake rhythm and the functioning of our immune system and nervous system. Our body makes its own histamine and stores it largely in so-called ‘mast’ cells. These specialized cells are located in tissues that are in contact with the outside world, such as the skin, lungs and gastrointestinal tract. Histamine can be released from the mast cells during an allergic reaction and it enters the blood. Medications, such as certain painkillers (ibuprofen and morphine, among others), antibiotics and drugs for high blood pressure, can also release histamine. A vitamin B12 injection also releases (a lot of) histamine from the mast cells. When there is a lot of free histamine in our body, there is an elevated histamine level. Histamine occurs naturally in many plant and animal products. In addition to the body’s own histamine, we also ingest it through our diet. In particular, fermented and mature foods contain a lot of histamine. Histamine from our food does not normally enter our bloodstream because the Diamine Oxidase enzyme (DAO) breaks it down in our intestines. With histamine intolerance, histamine is not broken down properly or at all, so histamine levels can become too high. Histamine levels that are too high can cause a variety of symptoms, such as itching, headaches and intestinal discomfort. The most common cause of histamine intolerance is a deficiency of the DAO enzyme, which prevents the histamine from your food from being broken down properly and ending up in your blood.
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