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How do I test my immune system level?

mayoclinic.org - Primary immunodeficiency - Diagnosis and treatment - Mayo Clinic

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Diagnosis

Your doctor will ask about your history of illnesses and whether any close relatives have an inherited immune system disorder. Your doctor will also perform a physical examination.

Tests used to diagnose an immune disorder include:

Blood tests. Blood tests can determine if you have typical levels of infection-fighting proteins (immunoglobulins) in your blood and measure the levels of blood cells and immune system cells. Having numbers of certain cells in your blood that are outside of the standard range can indicate an immune system defect. Blood tests can also determine if your immune system is responding properly and producing proteins that identify and kill foreign invaders such as bacteria or viruses (antibodies). Prenatal testing. Parents who have a child with a primary immunodeficiency disorder might want to be tested for certain immunodeficiency disorders during future pregnancies. Samples of the amniotic fluid, blood or cells from the tissue that will become the placenta (chorion) are tested for problems. In some cases, DNA testing is done to check for a genetic defect. Test results make it possible to prepare for treatment soon after birth, if necessary.

Treatment

Treatments for primary immunodeficiency involve preventing and treating infections, boosting the immune system, and treating the underlying cause of the immune problem. In some cases, primary immune disorders are linked to a serious illness, such as an autoimmune disorder or cancer, which also needs to be treated.

Managing infections

Treating infections. Infections require rapid and aggressive treatment with antibiotics. Treatment might require a longer course of antibiotics than is usually prescribed. Infections that don't respond may require hospitalization and intravenous (IV) antibiotics. Infections require rapid and aggressive treatment with antibiotics. Treatment might require a longer course of antibiotics than is usually prescribed. Infections that don't respond may require hospitalization and intravenous (IV) antibiotics. Preventing infections. Some people need long-term antibiotics to prevent respiratory infections and permanent damage to the lungs and ears. Children with primary immunodeficiency might not be able to have vaccines containing live viruses, such as oral polio and measles-mumps-rubella. Some people need long-term antibiotics to prevent respiratory infections and permanent damage to the lungs and ears. Children with primary immunodeficiency might not be able to have vaccines containing live viruses, such as oral polio and measles-mumps-rubella. Immunoglobulin therapy. Immunoglobulin consists of antibody proteins needed for the immune system to fight infections. It can either be injected into a vein through an IV line or inserted underneath the skin (subcutaneous infusion). IV treatment is needed every few weeks, and subcutaneous infusion is needed once or twice a week.

Treatment to reinstitute the immune system

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Stem cell transplantation. Stem cell transplantation offers a permanent cure for several forms of life-threatening immunodeficiency. Normal stem cells are transferred to the person with immunodeficiency, which results in a typically functioning immune system. Stem cells can be harvested through bone marrow, or they can be obtained from a placenta at birth (cord blood banking). The stem cell donor — usually a parent or other close relative — must have body tissues that are a close biological match to those of the person with primary immunodeficiency. Even with a good match, however, stem cell transplants don't always work. The treatment often requires that functioning immune cells be destroyed using chemotherapy or radiation before the transplants, leaving the transplant recipient temporarily even more vulnerable to infection. Gene therapy. This type of treatment involves taking stem cells from the person with primary immunodeficiency, correcting the gene in the cells and then returning the corrected stem cells back to the person via an intravenous infusion. With gene therapy, there is no need to find a suitable donor, as the person's own cells are used. Currently, this treatment is used to treat only a few primary immunodeficiencies, but clinical trials are underway for many other types. Depending on the type of disorder, treatment may involve other therapies, including enzyme replacement therapy or transplantation of the thymus, an organ located behind the breastbone (sternum) that produces T cells.

Clinical trials

Coping and support

Most people with primary immunodeficiency can go to school and work like everyone else. Still, you might feel as if no one understands what it's like to live with the constant threat of infections. Talking to someone who faces similar challenges may help. Ask your doctor if there are support groups in the area for people with primary immunodeficiency or for parents of children with the disease. The Immune Deficiency Foundation has a peer support program as well as information on living with primary immunodeficiency.

Preparing for your appointment

You'll likely start by seeing your family doctor or primary doctor. You might then be referred to a doctor who specializes in disorders of the immune system (immunologist).

Here's some information to help you get ready for your appointment.

What you can do

Write down symptoms, including any that may seem unrelated to the reason for your appointment, and when they began.

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including any that may seem unrelated to the reason for your appointment, and when they began. Bring copies of records from hospitalizations and medical test results, including X-rays, blood test results and culture findings. including X-rays, blood test results and culture findings. Ask family members about the family medical history, including whether anyone was diagnosed with primary immunodeficiency, or if your family has babies or children who died of unknown causes. including whether anyone was diagnosed with primary immunodeficiency, or if your family has babies or children who died of unknown causes. Make a list of medications, vitamins and supplements you or your child takes, including doses. If possible, list all of the antibiotic prescriptions and the dosages you or your child has taken for the past several months. vitamins and supplements you or your child takes, including doses. If possible, list all of the antibiotic prescriptions and the dosages you or your child has taken for the past several months. Write down questions to ask your doctor. Ask a family member or friend to come with you, if possible, to help you remember the information you're given.

For primary immunodeficiency, questions to ask your doctor include:

What's the most likely cause of these symptoms?

Are there other possible causes?

What tests are needed? Do these tests require special preparation?

What's the prognosis?

What treatments are available, and which do you recommend?

I have other health problems, how do I manage them together.

Are there alternatives to the primary approach you're suggesting?

Are there activity restrictions?

Are there brochures or other printed material I can have? What websites do you recommend?

Don't hesitate to ask any other questions, as well.

What to expect from your doctor

Your doctor or your child's doctor is likely to ask you questions, including:

mayoclinic.org - Primary immunodeficiency - Diagnosis and treatment - Mayo Clinic

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