Does quercetin lower eye pressure?

There is no direct evidence that Quercetin could have an IOP lowering effect on the eye. Its purported benefit to patients with glaucoma is related to its neuroprotective effect. The eye naturally produces enzymes called Peroxiredoxins (PRDXs) which neutralize hydrogen peroxide.

new-glaucoma-treatments.com - Neuroprotective Effect of Quercetin Against Glaucoma Damage

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Neuroprotective Effect of Quercetin Against Glaucoma Damage

What is Quercetin?

Quercetin is a member of the flavonoid family of naturally occurring compounds. It can be found in apples, asparagus, berries (such as bilberries, black currants, and alpine cranberries) broccoli, Ginkgo biloba,[1] green beans, kale, onions, red wine, tea, and tomatoes.[2] It is most concentrated in the leaves and skin of fruits and vegetables. When modified by the addition of rutinose (a sugar) Quercetin is known as Rutin.[3] There is laboratory evidence that it has antioxidant[4] and anti-inflammatory[5] properties. At higher doses, however, it may also increase oxidative damage.[6] Additionally, the anti-inflammatory properties noted in the laboratory may not be active in the body.[7] Its potential benefit as an oral supplement, however, is limited by low bioavailability (the amount ingested that is actually absorbed into the bloodstream). Once in the bloodstream evidence suggests that only a small percentage of it crosses the blood-brain barrier.[8] However, once in the brain it appears to have both an anti-inflammatory[9] and neuroprotective[10] effect, at least in concentrations expected from moderate oral supplementation.[11] In higher concentrations, however, Quercetin may be toxic to neurons.[12] Neuroprotective Effect of Quercetin. Evidence that Quercetin can be effective in the treatment of Glaucoma There is no direct evidence that Quercetin could have an IOP lowering effect on the eye. Its purported benefit to patients with glaucoma is related to its neuroprotective effect.[13] The eye naturally produces enzymes called Peroxiredoxins (PRDXs) which neutralize hydrogen peroxide. Quercetin has been shown in the laboratory to increase the production of Peroxiredoxins by trabecular meshwork cells.[14]

Potential Side Effects and Risks:

Quercetin appears to be safe when used orally in amounts up to 1,000mg per day for up to three months.[15] Longer term studies are not available so chronic, ongoing use may or may not be safe. Additionally, intravenous (IV) quercetin has been associated with kidney damage.[16] Side effects of oral Quercetin include headaches and tingling of the arms and/or legs.[17] There is some evidence that Quercetin may worsen memory performance.[18]

Potential Drug Interactions

Blood Thinners

Research suggests that Quercetin may limit the ability of platelets to clump.[19]This could increase the risk of bleeding when used with ”blood thinning” medications. Therefore, use of Quercetin may result in undesirable bleeding in those who are already taking anticoagulant medications such as aspirin, apixaban (Eliquis), clopidogrel (Plavix), dabigatran (Pradaxa), rivaroxaban (Xarelto) and warfarin (Coumadin).

Anti-Hypertensive Medications

Quercetin may lower blood pressure.[20] In those whose blood pressure is not well-controlled this could be a good thing. However, care should be taken when used along with other blood-pressure lowering medications such as captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), as well as many others.

Potential Interactions with Other Supplement

Resveratrol

Quercetin can increase the intestinal absorption of Resveratrol.[21] For those taking Resveratrol this interaction is most likely desirable.

Green Tea Catechins

Quercetin can increase the intestinal absorption of Green Tea Catechins. For those taking Green Tea Catechins this interaction is most likely desirable.

Recommended Dosage

As no human glaucoma studies have been done looking at the role of quercetin, it is not possible to recommend a proper dosage. For those who desire to take this supplement, however, it is worth noting that the dihydrate form of Quercetin appears to have the best bioavailability. Another option would be to take Rutin instead of Quercetin.

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What drugs interfere with quercetin?

Be careful if you are taking drugs such as antibiotics, cyclosporine, warfarin, or drugs that are changed by the liver. Quercetin may change how these drugs work and raise the risk of side effects. There don't appear to be interactions between quercetin and foods or other herbs and supplements.

webmd.com - Quercetin: Uses and Risks - WebMD

Quercetin is a plant pigment (flavonoid) that people sometimes take as a medicine. It is found in many plants and foods. Most studies look at the impact of flavonoids like quercetin within the diet rather than as a supplement. Why do people take quercetin? People take quercetin to try to manage a variety of issues, including: Heart and vessel problems

Lowering blood pressure

Prostate infections

Preventing upper respiratory infections

Allergies

Disease prevention Early quercetin research on heart and vessel disease is mixed. Some study results are positive but some are open to debate. For example, researchers link eating lots of foods high in quercetin to a lower risk of heart-related death in older men. But other studies are less convincing. Some research suggests that oral doses of quercetin may decrease pain from prostate infections. Some athletes try to increase endurance and improve athletic performance by using quercetin. Although animal studies are promising, the effects in humans, if any, are likely small. One of the biggest benefits to athletes taking quercetin is in protection from URI after intense workouts.

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