Smoothy Slim
Smoothy Slim
Photo: Mikhail Nilov
Eating fewer calories may slow down aging and increase longevity. Eating less may lengthen your life. Researchers have increased life-spans in yeast and mice by having them consume fewer calories per day, and ongoing studies suggest that a strict low-calorie diet may slow aging in primates, too.
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A scrumptious morning smoothy based on the diets of among the healthiest, longest-living hamlet in the world.
Learn More »Eating less may lengthen your life. Researchers have increased life-spans in yeast and mice by having them consume fewer calories per day, and ongoing studies suggest that a strict low-calorie diet may slow aging in primates, too. But the mechanism behind the gains has puzzled scientists for years. Now a study published in the 22 September issue of Science uncovers the first genetic clue to how eating less may increase longevity. Cutting yeast cells' glucose intake by as much as 75% increases their life-span by 25%, says molecular biologist Leonard Guarente from the Massachusetts Institute of Technology. To hunt down genes involved in the change, Guarente and his team first knocked out a gene called SIR2, known to be important in yeast's life-span. A restricted diet didn't help these altered cells live longer, confirming that SIR2 plays a key role in this type of life-span extension. But because SIR2 requires a molecule called NAD for activation, Guarente then deleted another gene, called NPT1, which is involved in making NAD. Cells lacking NPT1 did not benefit from caloric restriction either, reinforcing the idea that SIR2 has an important role in extending life. But how? Guarente says that in cells on a strict diet, more NAD is available to SIR2, increasing its activity. SIR2, in turn, "silences" certain other genes, reducing harmful chromosomal changes by encoding a protein that prevents a gene from being copied. SIR2 also suppresses the formation of short, circular DNA fragments, which accumulate with age and are known to shorten yeast's life-span. Together, the changes appear to help increase life-span. The discovery may have relevance for people: Although mammals don't accumulate DNA circles with age, a SIR2-like gene, regulated by NAD, silences our chromosomes too. If that gene proves important in aging, Guarente says, it may provide "one of the most promising avenues toward getting a drug that would affect the aging process." Aging researcher Judith Campisi of the Lawrence Berkeley National Laboratory agrees that SIR2 "provides a molecular clue" to aging, but warns the discovery is a far cry from the fountain of youth some people dream about. Still, she says, "I'm encouraged that we will learn quite a lot about human aging from this study."
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A scrumptious morning smoothy based on the diets of among the healthiest, longest-living hamlet in the world.
Learn More »Yucca. One word: Cyanide! This root vegetable, a staple of South American cuisine, is packed with vitamins and minerals. But it's also hiding a sneaky, potentially lethal ingredient.
6 / 13 Shutterstock / leonori Sprouts Alfalfa and radish sprouts can contain pesky harmful bacteria like E. coli, Salmonella and Listeria. Sprouts are grown in warm, moist conditions where these bacteria thrive. Because of this, you should aim to buy your sprouts as fresh as possible; consider buying them locally or from a farmers’ market. And, of course, wash them and cook them. 7 / 13 Janthiwa Sutthiboriban/Shutterstock Bitter almonds The almonds that we know and love are also called “sweet almonds,” and there are some excellent health reasons to eat them. Bitter almonds are kind of like their evil cousin. They’re a variety of sweet almonds, but they contain hydrocyanic acid, which is a dangerous combo of hydrogen cyanide and water. According to the Spruce, it would only take about 70 raw bitter almonds to kill a fully grown adult. Yikes! Thankfully, they’re safe to eat if they’ve been cooked, and most U.S. grocery stores don’t sell them. The likeliest places you’ll encounter them are in almond extract and almond-flavored liqueurs. Here are 8 healthy ways you can add nuts to your diet.
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