Can testosterone shots mess with your heart?

Men taking testosterone therapy are at no greater risk of heart attack during their first year of treatment.

imperial.ac.uk - Testosterone treatment does not increase risk of heart attack

When should I stop showering with my daughter?

In general, I would say that by the age of 8 or 9 years-10 at the latest-most children have developed enough of a sense of personal boundaries and...

Last updated Nov 2, 2020

Can I sleep with vitamin C serum on my face?

A Vitamin C serum should be used in your bedtime routine and a couple of drops of it should suffice. Tap it on your skin using your fingertips and...

Last updated Jul 28, 2019

Tasty juice “eats through” 54lbs of thick flab

This effective juice jolts the metabolism, boosts energy and burns fat all day.

Learn More »

Promotion

Men taking testosterone therapy are at no greater risk of heart attack during their first year of treatment. In the most comprehensive review of available evidence to date, researchers have shown that testosterone replacement therapy appears safe for use in the short-to-medium term to treat a condition caused by deficiency of the male sex hormone. Testosterone replacement therapy is the standard treatment for hypogonadism, which can cause sexual dysfunction, weakening of bones and muscles, and reduced quality of life. While our study does not look at the longer-term safety of the treatment, these findings will enable doctors to be more confident prescribing testosterone to men who need it.” Dr Channa Jayasena Department of Metabolism, Digestion & Reproduction But current guidelines are unclear on whether the treatment is associated with any increased cardiovascular risk. The US Food & Drugs Agency (FDA) has a safety warning about testosterone and heart disease, but the European Medicines Agency (EMA) has concluded that there is not enough information to say that testosterone causes heart problems. The lack of agreement about testosterone’s safety makes doctors and patients uncertain about the risks. But findings presented today at the at the ENDO 2022 congress in the United States and published in the journal The Lancet Healthy Longevity, suggest that men given testosterone to treat hypogonadism are at no greater risk of heart attack, stroke and other cardiovascular events, or death, in the short-to-medium term than men who do not receive testosterone treatment.

No increased risk

In a meta-analysis, researchers looked at 17 trials involving nearly 3,500 participants, around half of which received testosterone, while half received a placebo. They found no significant increase in cardiovascular events between the testosterone and placebo groups (7.5% vs 7.2%, respectively), or mortality rate (0.4% vs 0.8%, respectively). They found that testosterone significantly reduced some key markers of cardiovascular health, including serum total cholesterol, high-density lipoprotein (HDL), and triglycerides compared with placebo. However, there were no significant differences in serum low-density lipoprotein (LDL), blood pressure, incidence of diabetes and prostate adverse outcomes between the testosterone and placebo groups. Dr Channa Jayasena, from Imperial College London, senior author on the paper, said: “Most men who need testosterone treatment are 50 years or older, an age at which risk factors for heart problems become more common. The majority of current guidelines say that previous studies have contradictory results about the heart safety of testosterone treatment. It is therefore likely that some men with symptomatic low testosterone are being deprived treatment due to these concerns. “Our study is likely to supersede the previous evidence and suggests that, within the first year of treatment at least, testosterone treatment is not associated with heart problems. While our study does not look at the longer-term safety of the treatment, these findings will enable doctors to be more confident prescribing testosterone to men who need it.”

-

‘Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis’ by Jemma Hudson et al. is published in The Lancet Healthy Longevity. DOI: 10.1016/S2666-7568(22)00096-4

This article is based on press materials from The Lancet.

What is the best snack for weight loss?

Here are 29 healthy, weight-loss-friendly snacks to add to your diet. Mixed nuts. ... Red bell pepper with guacamole. ... Greek yogurt and mixed...

Last updated Apr 15, 2018

What is average shoe size for a woman?

between 8.5 and 9 Feet have gotten larger, too. While there are no official statistics about shoe sizes, anecdotally, the average shoe size for...

Last updated Jun 26, 2022

Tasty breakfast juice melts 59lbs of wobbly fat

A scrumptious morning smoothy based on the diets of among the healthiest, longest-living hamlet in the world.

Learn More »

Promotion

How can I lose belly and liver fat?

Now comes a study that suggests overweight adults who do even 15 minutes of daily exercise —regardless of intensity or weight loss— can reduce the...

Last updated Feb 22, 2021

Why do healthy people have high blood pressure?

Causes of High Blood Pressure Lack of physical activity. High-sodium diet. Heavy alcohol consumption (more than 1 to 2 drinks per day)

Last updated Sep 10, 2022

Traditional “juice” activates 24/7 fat-burning

A potent powdered supplement blended right into water or your favored beverage to be appreciated as a scrumptious morning smoothy.

Learn More »

Promotion

Where is liver pain felt?

Pain in your liver itself can feel like a dull throbbing pain or a stabbing sensation in your right upper abdomen just under your ribs. General...

Last updated Aug 29, 2019

Fizzy juice “eats through” 59lbs of stubborn fat

This effective juice jolts the metabolism, boosts energy and burns fat all day.

Learn More »

Promotion

What foods shrink your stomach?

Eight Delicious Foods That Help Fight Belly Fat Belly Fat-Fighting Foods. Avocados. Bananas. Yogurt. Berries. Chocolate Skim Milk. Green Tea....

Last updated Mar 18, 2019