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Can I apply hyaluronic acid after vitamin C?

A thick moisturizer with hyaluronic acid would be applied after a vitamin C serum, but a hyaluronic acid serum will come before a face cream with vitamin C in its formula. In the case that you have two separate serums, it still comes down to thickness. Apply whichever is thinner first.

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Can You Use Hyaluronic Acid and Vitamin C Together?

Not all powerful skincare ingredients can be mixed, but hyaluronic acid and vitamin C are two that become even stronger when paired with one another. These ingredients can provide both immediate and lasting results when used together in anti-aging formulations. One study on a serum made with L-ascorbic acid and hyaluronic acid found that the formula visibly reduced wrinkles, improved skin brightness, and left participants with more hydrated skin.I These impressive benefits are why we combine hyaluronic acid and vitamin C in our Powerful-Strength Line-Reducing collection. The bestselling Powerful-Strength Vitamin C Serum is formulated with two different types of vitamin C—L-ascorbic acid and ascorbyl glucoside. The result is a multi-benefit vitamin C serum that instantly smooths skin’s texture and visibly reduces fine lines and wrinkles while improving the appearance of skin’s radiance and texture. It also contains fragmented hyaluronic acid—a shorter-length hyaluronic acid that is better able to penetrate surface layers of the skin. This allows for more moisture to be drawn into the epidermis, plumping the appearance of fine lines and smoothing out the look and feel of rough texture. The line also includes Powerful-Strength Dark Circle Reducing Vitamin C Eye Serum, which has earned a fan in celebrity aesthetician Shamara Bondaroff. She says, “What’s so great about this product is it hits the brown and blue under-eye issues—not a lot of products do that.” Dark circles can be either brown or blue in color, and some formulas may only address one type or the other. As a skincare expert, Bondaroff also recognizes the value of using both vitamin C and hyaluronic acid. She shares, “I am a huge fan of vitamin C, not only ingesting it but using it topically because it’s an antioxidant.” Hyaluronic acid also earns points in her book, thanks to its ability to take away the look of dryness and make skin appear plumper. The benefits she calls out shine in our gentle eye creams, which are clinically proven to help decrease the appearance of lines, crow’s feet, and dark under-eye circles.*

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Does vitamin C increase wrinkles?

A few clinical studies have demonstrated that vitamin C can improve wrinkles. One study showed that daily use of a vitamin C formulation for at least three months improved the appearance of fine and coarse wrinkles of the face and neck, as well as improved overall skin texture and appearance.

November 10, 2021

Dr. Payal Patel is a dermatology research fellow at Massachusetts General Hospital. Her clinical and research interests include autoimmune disease and procedural dermatology. She is part of the Cutaneous Biology Research Center, where she investigates medical … See Full Bio Dr. Neera Nathan is a dermatologist and researcher at Massachusetts General Hospital and Lahey Hospital and Medical Center. Her clinical and research interests include dermatologic surgery, cosmetic dermatology, and laser medicine. She is part of the … See Full Bio As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.

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