At what age do you age the most?

The results offer important new insights into what happens as we age. For example, the team suggests that the biological aging process isn't steady and appears to accelerate periodically — with the greatest bursts coming, on average, around ages 34, 60, and 78.

nia.nih.gov - Aging research: Blood proteins show your age - National Institute on Aging

What is the drink that shrinks belly fat?

Green TeaOn the top of the list is green tea which is packed with antioxidants known as catechins that are believed to fight the stubborn belly...

Last updated Jul 16, 2019

Do apples clean your stomach?

Pectin content in apples can absorb the water present in the intestines, softening the stool and help the body eliminate heavy metals and toxins....

Last updated May 14, 2022

Common yard weed melts 60lbs of fat?

Made into a potent powdered supplement blended right into water or your favorite beverage to be appreciated as a scrumptious morning smoothy.

Learn More »

Promotion

From the NIH Director’s Blog by Dr. Francis Collins

How can you tell how old someone is? Of course, you could scan their driver’s license or look for signs of facial wrinkles and gray hair. But, as researchers just found in a new study, you also could get pretty close to the answer by doing a blood test. That may seem surprising. But in a recent study in Nature Medicine, an NIH-funded research team was able to gauge a person’s age quite reliably by analyzing a blood sample for levels of a few hundred proteins. The results offer important new insights into what happens as we age. For example, the team suggests that the biological aging process isn’t steady and appears to accelerate periodically — with the greatest bursts coming, on average, around ages 34, 60, and 78. These findings indicate that it may be possible one day to devise a blood test to identify individuals who are aging faster biologically than others. Such folks might be at risk earlier in life for cardiovascular problems, Alzheimer’s disease, osteoarthritis, and other age-related health issues. What’s more, this work raises hope for interventions that may slow down the “proteomic clock” and perhaps help to keep people biologically younger than their chronological age. Such a scenario might sound like pure fantasy, but this same group of researchers showed a few years ago that it’s indeed possible to rejuvenate an older mouse by infusing blood from a much younger mouse. Those and other earlier findings from the lab of Tony Wyss-Coray, Stanford School of Medicine, Palo Alto, CA, raised the tantalizing possibility that certain substances in young blood can revitalize the aging brain and other parts of the body. In search of additional clues in the new study, the Wyss-Coray team tracked how the protein composition of blood changes as people age. To find those clues, they isolated plasma from more than 4,200 healthy individuals between ages 18 and 95. The researchers then used data from more than half of the participants to assemble a “proteomic clock” of aging. Within certain limits, the clock could accurately predict the chronological age of the study’s remaining 1,446 participants. The best predictions relied on just 373 of the clock’s almost 3,000 proteins. As further validation, the clock also reliably predicted the correct chronological age of four groups of people not in the study. Interestingly, it was possible to make a decent age prediction based on just nine of the clock’s most informative proteins. The findings show that telltale proteomic changes arise with age, and they likely have important and as-yet unknown health implications. After all, those proteins found circulating in the bloodstream come not just from blood cells but also from cells throughout the body. Intriguingly, the researchers report that people who appeared biologically younger than their actual chronological age based on their blood proteins also performed better on cognitive and physical tests.

Are beets a superfood?

Beetroot is a superfood. We'll tell you what makes it so good for you. A superfood is a nutrient-rich food that contains an above-average amount of...

Last updated Aug 29, 2019

What foods are 100% good for you?

Top 100 Most Nutritious Foods In the World 1) Almonds. Rich in mono-unsaturated fatty acids. ... 2) Cherimoya. Cherimoya fruit is fleshy and sweet...

Last updated Apr 23, 2018

Strange purple cocktail removes 2.7lbs every 4 days

This effective juice jolts the metabolism, boosts energy and burns fat all day.

Learn More »

Promotion

Most of us view aging as a gradual, linear process. However, the protein evidence suggests that, biologically, aging follows a more complex pattern. Some proteins did gradually tick up or down over time in an almost linear fashion. But the levels of many other proteins rose or fell more markedly over time. For instance, one neural protein in the blood stayed constant until around age 60, when its levels spiked. Why that is so remains to be determined. As noted, the researchers found evidence that the aging process includes a series of three bursts. Wyss-Coray said he found it especially interesting that the first burst happens in early mid-life, around age 34, well before common signs of aging and its associated health problems would manifest. It’s also well known that men and women age differently, and this study adds to that evidence. About two-thirds of the proteins that changed with age also differed between the sexes. However, because the effect of aging on the most important proteins of the clock is much stronger than the differences in gender, the proteomic clock still could accurately predict the ages in all people. Overall, the findings show that protein substances in blood can serve as a useful measure of a person’s chronological and biological age and — together with Wyss-Coray’s earlier studies — that substances in blood may play an active role in the aging process. Wyss-Coray reports that his team continues to dig deeper into its data, hoping to learn more about the origins of particular proteins in the bloodstream, what they mean for our health, and how to potentially turn back the proteomic clock.

Reference:

[1 ] Lehallier B, et al. Undulating changes in human plasma proteome profiles across the lifespan. Nat Med. 2019 Dec;25(12):1843-1850.

NIH Support: National Institute on Aging

nia.nih.gov - Aging research: Blood proteins show your age - National Institute on Aging

What makes a smoothie unhealthy?

Smoothies are high in sugar. Free sugars include any added sugars (including honey and maple syrup) and are the kind we should all be cutting down...

Last updated May 16, 2020

What BP puts you at risk for stroke?

Blood pressure of 140/90 or higher can damage blood vessels (arteries) that supply blood to the brain. Heart disease. Heart disease is the second...

Last updated Feb 13, 2021

Common yard weed melts 60lbs of fat?

Made into a potent powdered supplement blended right into water or your favorite beverage to be appreciated as a scrumptious morning smoothy.

Learn More »

Promotion

What vitamin is best to fight colds?

Vitamin C. Vitamin C is marketed as the go-to supplement for preventing and treating colds. Mechanistically, it makes sense: vitamin C helps immune...

Last updated Dec 14, 2019

7-second natural hack eats through 64lbs of belly flab

This effective juice jolts the metabolism, boosts energy and burns fat all day.

Learn More »

Promotion

Can vitamin E remove dark spots?

Protecting from discoloration: If you are prone to dark spots or hyperpigmentation, mixing vitamin E into your skincare routine could be...

Last updated Mar 9, 2021